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AZ-23
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZ-23图片
CAS NO:915720-21-7
包装与价格:
包装价格(元)
5 mg电议
100 mg电议
500 mg电议

产品名称
AZ23
AZ 23
产品介绍
AZ-23是一种 ATP-竞争性的,口服具有活性的Trk激酶 A/B/C抑制剂,IC50值分别为2 nM (TrkA),8 nM (TrkB),24 nM (FGFR1),52 nM (FLT3),55 nM (Ret),84 nM (MuSk),99 nM (Lck)。

产品描述

AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.

体外活性

AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC50 of 2 nM) and it also Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines[1].

体内活性

AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model. And it significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma[1].

Cas No.

915720-21-7

分子式

C17H19ClFN7O

分子量

391.83

别名

AZ23;AZ 23

储存和溶解度

DMSO:125 mg/mL (319.02 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years