AZD3229 是一种突变型酪氨酸激酶受体抑制剂，可用于胃肠道间质瘤的研究。

AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. It demonstrates potent single-digit nM growth inhibition across a broad cell panel.

Following a single dose (AZD3229, 20 mg/kg), high free cover over the target is achieved and is associated with complete suppression of pKIT and downstream markers out to 8 hours. As the compound is cleared and cover declines, these signals recover although recovery is not complete even at 24 hours.

2248003-60-1

C24H26FN7O3

479.516

H2O:Insoluble
DMSO:95 mg/mL (198.12 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years