dTRIM24, based on PROTAC, is a selective bifunctional TRIM24 degrader.

dTRIM24 suppresses growth to a greater extent than does IACS-9571, accompanied by apoptosis measured as enhanced PARP cleavage. Recruitment of the VHL E3 ubiquitin ligase by dTRIM24 elicits potent and selective degradation of TRIM24. Growth over time is determined for MOLM-13 cells treated with dTRIM24, IACS-9571, VL-269, and eTRIM24. Near-complete degradation of TRIM24 is observed in dTRIM24-treated cells throughout the duration of the experiment, which is consistent with a sustained proliferative defect observed following dTRIM24 treatment [2].

2170695-14-2

C55H68N8O13S2

1113.3

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years