产品描述
EN460 is an inhibitor of endoplasmic reticulum oxidation 1 (ERO1) and interacts selectively (IC50: 1.9 uM) with the reduced, active form of ERO1α and prevents its reoxidation.
体外活性
Exposure of cells to EN460 or QM295 resulted in the accumulation of an ERO1α form with lower mobility, indicative of the reduced state. EN460 and QM295 activate an unfolded protein response reporter in cultured 293T cells.
Cas No.
496807-64-8
分子式
C22H12ClF3N2O4
分子量
460.79
储存和溶解度
DMSO:12.5 mg/mL (27.13 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years