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CUDC-427
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CUDC-427图片
CAS NO:1446182-94-0
包装:100 mg
市场价:14106元

产品名称
GDC-0917
产品介绍

产品描述

CUDC-427 is an antagonist of second-generation pan-selective IAP used for the treatment of various cancers.

体外活性

GDC-0917 (0.1 nM-10 μM) induces the reduction of cIAP1 levels in PBMCs in a concentration-dependent manner. It showing greater than 80% inhibition at concentrations greater than 0.1 μM (56.5 ng/mL).

体内活性

GDC-0917 is well tolerated, with all dose groups experiencing a<11% decrease in mean body weight. GDC-0917 (0.08-16.3 mg/kg) shows antitumor activity in a dose-dependent manner in the MDA-MB-231-X1.1 Breast Cancer Xenograft. GDC-0917 has low to moderate clearance in the mouse (12.0 mL/min/kg), rat (27.0 mL/min/kg), and dog (15.3 mL/min/kg), and high clearance in the monkey (67.6 mL/min/kg).

Cas No.

1446182-94-0

分子式

C29H36N6O4S

分子量

564.7

别名

GDC-0917

储存和溶解度

DMSO:100 mg/mL (177.09 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years