您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > GLP-1(28-36)amide acetate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
GLP-1(28-36)amide acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GLP-1(28-36)amide acetate图片
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
GLP-1(28-36)amide acetate(1225021-13-5 Free base)
产品介绍
GLP-1(28-36)amide acetate 抑制线粒体通透性转变,具有抗氧化、抗糖尿病和心脏保护活性。

产品描述

GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities.

体外活性

The plasma half-life of GLP-1(28-36)amide acetate is longer in human hepatocytes (24 min) than that in mouse hepatocytes (13 min). GLP-1(28-36)amide acetate (100 nM) on hepatocytes modulates mitochondrial oxidative metabolism including gluconeogenesis in mitochondria of hepatocytes[1].

体内活性

In high-fat diet-fed mice, GLP-1(28-36)amide acetate (18.5 nmol/kg) improved hepatic glucose disposal. In diet-induced obese mice, GLP-1(28-36)amide acetate (18.5 nmol/kg BW/day) diminishes the development of hepatic steatosis. In male C57BL6/J mice, administration of GLP-1(28-36)amide acetate for 20 min to, then isolated hearts underwent 30 min of global ischemia and 40 min of reperfusion, the recovery of left ventricular developed pressure is significantly great. In a β-cell injury diabetic mouse model, GLP-1(28-36)amide acetate (18 nmol/kg; i.p.) shows cytoprotective effect on pancreatic β cells by promoting proliferation and increasing mass[1].

Cas No.

T37890L

分子式

C56H89N15O11

分子量

1148.4

别名

GLP-1(28-36)amide acetate(1225021-13-5 Free base)

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years