BGT226 是一种PI3K/mTOR双抑制剂，对PI3Kα、PI3Kβ和PI3Kγ的IC50分别是4 nM、63 nM和38 nM。它有效抑制人头颈癌细胞的生长。

Bgt226 is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.

Growth inhibition experiment showed that BGT226 had antitumor activity. BGT226 significantly inhibited cell growth with IC50< 20 nM. BGT226 also induced cancer cell apoptosis at nanomolar concentration, IC50 ≤ 25 nM[1][2][3].

BGT226 significantly delayed tumor growth on the transplanted tumor animal model. This effect was dose-dependent, accompanied by inhibition of p-p70 S6 kinase cytoplasmic expression and autophagy body formation[2].

915020-55-2

C28H25F3N6O2

534.543

BGT226 free base;NVP-BGT226

DMSO:65 mg/ml (121.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years