Chk1-IN-3 是一种检测点激酶 (Chk1) 抑制剂,IC50 值为 0.4 nM。
产品描述
CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).
体外活性
CHK1-IN-3 displays a low affinity for hERG (IC50 >40 μM). CHK1-IN-3 effectively inhibits the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 μM)[1].
体内活性
In the Z-138 cell inoculated xenograft model, CHK1-IN-3 significantly suppresses the tumor growth as a single agent with bodyweight unaffected[1].
Cas No.
2097252-39-4
分子式
C20H23N9O
分子量
405.46
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years