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Carperitide acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Carperitide acetate图片
CAS NO:1366000-58-9
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
25 mg电议
100 mg电议

产品名称
醋酸卡培立肽
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate
产品介绍
Carperitide acetate是一种由 28 个氨基酸组成的激素,由心脏产生并分泌,以响应心脏损伤和机械拉伸。Carperitide acetate 抑制内皮素-1 (endothelin-1) 分泌。

产品描述

Carperitide acetateis a 28-amino acid hormone. Carperitide acetate is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.

体外活性

Atrial natriuretic peptide (ANP) is a diuretic, natriuretic, and vasodilatory peptide hormone originally isolated from mammalian hearts. In cultured porcine endothelial cells the inhibition by porcine ANP (1-28) of immunoreactive endothelin-1 secretion after stimulation with Angiotensin II (Ang II) is paralleled by an increase in the cellular cGMP level. Porcine ANP (1-28) strongly inhibits immunoreactive endothelin-1 secretion in porcine aorta after stimulation with Ang II[1]. ANP is a cardiac hormone involved in electrolyte and fluid homeostasis. The inhibition by ANP of endothelin-1 secretion stimulated by angiotensin II (ANGII) and thrombin using cultured human umbilical-vein endothelial cells. Human ANP (1-28) inhibits immunoreactive (ir)-endothelin-1 secretion and increases cyclic GMP in the human umbilical-vein endothelial cells[2]. In glomeruli from normal rats, Human 125I-ANP (1-28) binds to a single population of high affinity receptors with a mean equilibrium dissociation constant of 0.46 nM. Human ANP (1-28) binds to the glomerular ANP receptor with high affinity stimulated cGMP accumulation. Human ANP (1-28) markedly stimulates cGMP generation, but not cAMP generation in normal rat glomeruli[3].

Cas No.

1366000-58-9

分子式

C129H207N45O41S3

分子量

3140.50

别名

醋酸卡培立肽;Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate

储存和溶解度

H2O:100mg/mL (32.46mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years