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TM38837
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TM38837图片
CAS NO:1253641-65-4
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议

产品介绍
TM38837 是外周选择性大麻素受体1型受体拮抗剂。它减少精神病副作用的倾向。它对大脑的渗透率有限,以最小化或防止 CNS 不良反应,并保留潜在的抗肥胖作用。

产品描述

TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.

体内活性

TM38837, a novel, largely peripherally restricted CB1 antagonist, in terms of fear-promoting consequences of systemic vs. intracerebral injections.?Different groups of male C57BL/6 N mice underwent auditory fear conditioning, followed by re-exposure to the tone.?Mice were treated per os (p.o.) with TM38837 (10, 30, or 100 mg/kg), rimonabant (10 mg/kg;?a brain penetrating CB1 antagonist/inverse agonist which served as a positive control), or vehicle, 2 h prior the tone presentation.?Only the high dose of TM38837 (100 mg/kg) induced a significant increase in freezing behavior, similar to that induced by rimonabant (10 mg/kg) (p

Cas No.

1253641-65-4

分子式

C30H25Cl2F3N4OS

分子量

617.51

储存和溶解度

DMSO:40 mg/mL (64.77 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years