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BAY 38-7271
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BAY 38-7271图片
CAS NO:212188-60-8
包装与价格:
包装价格(元)
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品介绍

产品描述

BAY 38-7271 has strong neuroprotective properties.[1] BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist. With Kis of 1.85 nM and 5.96 nM for recombinant human CB1 receptor and CB2 receptor, respectively.

体外活性

BAY 38-7271 shows only minor interactions at the micromolar range with other binding sites such as adenosine A3 receptor (IC50 = 7.5 μM), peripheral GABAA benzodiazepine receptor (IC50 = 971 nM), at the monoamine transporter (IC50 = 1.7 μM), and melatonin ML1 receptor (IC50 = 3.3 μM)[1].

体内活性

BAY 38-7271 (Ed50 = 0.02 mg/kg; i.v. and 0.5 mg/kg; i.p.) induces a potent and dose-de-pendent reduction in core body temperature[1]. BAY 38-7271 (1-1000 ng/kg/h; i.v. infusion; for 4 hours) shows neuroprotective efficacy in the rat SDH model[1]. BAY 38-7271 has low physical dependence liability and is not essentially different from that of other cannabinoid CB1 receptor agonists[1] and it also has neuroprotective efficacy in models of transient and permanent occlusion of the middle cerebral artery and brain edema models[1].

Cas No.

212188-60-8

分子式

C20H21F3O5S

分子量

430.44

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years