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HSK0935
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HSK0935图片
CAS NO:1638851-44-1
包装:5 mg
市场价:9850元

产品名称
HSK-0935
HSK 0935
产品介绍

产品描述

HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.

体外活性

HSK0935 shows excellent hSGLT2 inhibition of 1.3 nM. HSK0935 displays a high hSGLT1/hSGLT2 selectivity of 843-fold[1].

体内活性

HSK0935 is well tolerated up to 300 mg/kg without any mortality or severe untoward effects in a 28-day repeat-dose toxicology study in beagle dogs. HSK0935 treatment (1, 3, and 10 mg/kg) displays robust urinary glucose excretion in Sprague?Dawley (SD) rats and affects more urinary glucose excretion in Rhesus monkeys[1].

Cas No.

1638851-44-1

分子式

C22H25ClO7

分子量

436.88

别名

HSK-0935;HSK 0935

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years