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MP-A08
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MP-A08图片
CAS NO:219832-49-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
MP-A08 是高度选择性和 ATP 竞争性的 SPHK1 抑制剂。

产品描述

MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively).

体外活性

MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type. MP-A08 blocks pro-proliferative signaling pathways causes mitochondrial-associated apoptosis in an SK-dependent manner. It also reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis [2]

体内活性

MP-A08 inhibits the growth of human lung tumour xenografts in mice.

Cas No.

219832-49-2

分子式

C27H25N3O4S2

分子量

519.64

储存和溶解度

H2O:insoluble
DMSO:50 mg/mL (96.22 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years