您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > K145 hydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
K145 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
K145 hydrochloride图片
CAS NO:1449240-68-9
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
K145盐酸盐
产品介绍
K145 hydrochloride 是选择性的,底物竞争性的和口服有效的SphK2抑制剂,IC50为 4.3 μM,Ki为 6.4 μM。它可诱导细胞凋亡,显示出强大的抗肿瘤活性。

产品描述

K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 μM and Ki of 6.4 μM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.

体外活性

K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30 uM. The Lineweaver-Burk analysis revealed a Ki of 6.4±0.7 uM for SphK2 and indicated that K145 is a substrate competitive inhibitor (with sphingosine). K145 accumulates in U937 cells, suppresses the S1P level, and inhibits SphK2. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells, and that these effects may be through the inhibition of downstream ERK and Akt signaling pathways.

Cas No.

1449240-68-9

分子式

C18H25ClN2O3S

分子量

384.92

别名

K145盐酸盐

储存和溶解度

H2O:125 mg/mL (324.74 mM),Need ultrasonic and warming
H2O:125 mg/mL (324.74 mM),Need ultrasonic and warming
DMSO:48 mg/mL (124.7 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years