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p-MPPI hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
p-MPPI hydrochloride图片
CAS NO:220643-77-6
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
500 mg电议

产品介绍
p-MPPI hydrochloride 是一种选择性的,具有高亲和力的5-HT1A受体拮抗剂,能穿过血脑屏障,具有抗抑郁和抗焦虑样作用。

产品描述

p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.

体内活性

pre-treatment with p-MPPI (5 mg/kg intraperitoneal (i.p.)) 30 min before 8-OH-DPAT (0.375 mg/kg subcutaneously (s.c.)) reduced the effect of 8-OH-DPAT on waking and REM sleep.?Also, p-MPPI (5 and 10 mg/kg i.p.) reduced the effect of 8-OH-DPAT on locomotion and partially or completely antagonized hindlimb abduction and flat body posture.?No overt behavioural change was produced by p-MPPI alone.?Thus, p-MPPI behaved as a true 5-HT(1A) antagonist.

动物实验

Animal Model:Adult male Swiss Webster mice (aged 8-9 weeks). Dosage:0.5, 1.5, 4.5 mg/kg. Administration:i.p.

Cas No.

220643-77-6

分子式

C25H28ClIN4O2

分子量

578.87

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years