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Cytosporone B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:321661-62-5
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Dothiorelone G
Csn-B
产品介绍
Cytosporone B 是一种天然存在的核孤儿受体Nur77/NR4A1激动剂(EC50=0.278 nM)。

产品描述

Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM). Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself. Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth. It also induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat and high cholesterol diet. Cytosporone B is brain penetrant and aggravates early brain injury in rats when given (13 mg/kg intraperitoneally) after experimentally-induced subarachnoid hemorrhage. Cytosporone B also has antibacterial properties.

Cas No.

321661-62-5

分子式

C18H26O5

分子量

322.4

别名

Dothiorelone G;Csn-B

储存和溶解度

DMSO:32.2 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years