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Pivagabine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pivagabine图片
CAS NO:69542-93-4
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
CXB-722
匹伐加宾
产品介绍
Pivagabine 是疏水性 4-氨基丁酸的衍生物,具有神经调节活性。它可穿透大鼠的血脑屏障,拮抗足部休克对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。

产品描述

Pivagabine is a derivative of hydrophobic 4-aminobutyric acid, with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain.

体内活性

Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions[2].

动物实验

Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions, reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex[2].

Cas No.

69542-93-4

分子式

C9H17NO3

分子量

187.24

别名

CXB-722;匹伐加宾

储存和溶解度

DMSO:49 mg/mL (261.69 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years