INCA-6 是活化 T 细胞核因子 (NFAT) 和 calcineurin-NFAT 信号传导的抑制剂。

INCA-6 is an inhibitor of Nuclear factor of activated T cells (NFAT) and calcineurin-NFAT signaling.

In human retinal microvascular endothelial cells, INCA-6 (1.0, 2.5 μM) significantly decreases VEGF and serum-induced proliferation without affecting baseline proliferation[1]. In 3-Hz cells, INCA-6 (5 μM) prevents transient outward K+ current downregulation[2]. INCA-6 (10 μM) significantly inhibits ATP-induced CXCL2 expression in rat primary microglia and BV-2 cells[3]. INCA-6 (5 μM) protein expression and reduces SERCA2 transcript levels with and without thapsigargin[4].

INCA-6 (2.5, 5.0, and 25.0 μM; intravitreal) significantly reduces pathologic neovascularization in oxygen-induced retinopathy and decreases the severity of OIR in a dose dependent manner[1].

3519-82-2

C20H12O2

284.31

Triptycene-1,4-quinone

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years