FT011 是抗纤维化剂，能够抑制胶原蛋白 I 和 III 的 mRNA 表达，减少胶原蛋白合成。

FT011, a direct anti-fibrotic agent,attenuates cardiac remodelling and dysfunction in experimental diabetic cardiomyopathy.

A direct anti-fibrotic agent, FT011, attenuates cardiac remodelling and dysfunction in experimental diabetic cardiomyopathy[1].

Homozygous Ren-2 rats were randomized to receive streptozotocin or vehicle then further randomized to FT011 (200 mg/kg/day) or vehicle treatment for 6 weeks. Prior to tissue collection, cardiac function was assessed via echocardiography and cardiac catheterization. Total collagen deposition and cardiomyocyte hypertrophy were assessed by picrosirius red and haematoxylin and eosin staining, respectively. Macrophage interstitial infiltration and type I and III collagen were quantitated by immunostaining[1].

1001288-58-9

C20H17NO5

351.358

DMSO:29 mg/mL (82.54 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years