您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > C 87
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
C 87
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
C 87图片
CAS NO:332420-90-3
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品介绍
C 87 是一种小分子 TNF-α 抑制剂。 C 87 直接与 TNFα 结合,有效抑制 TNF-α 诱导的细胞毒性 (IC50 = 8.73 μM),并有效阻断 TNF-α 触发的信号传导活动。

产品描述

C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.

体外活性

C 87 reduces the activity of c-Jun N-terminal kinase (JNK) in L929 cells. C 87 prevents the degradation of IκBα in cells treated with TNF-α and potently blocks multiple signaling transduction pathways and downstream target gene activation triggered by TNF-α. C 87 exhibits good solubility and consistent dose-dependent functions in vitro. C 87 completely blocks the TNFα-induced activation of caspase-3 and caspase-8[1].

体内活性

In mice, the level of alanine transaminase and aspartate transaminase is consistently reduced. C 87 markedly reduces injuries to the liver and improves animal survival. C 87 injection delays the incidence of death and increases the survival rate by two fo

Cas No.

332420-90-3

分子式

C24H15ClN6O3S

分子量

502.93

储存和溶解度

DMSO:5 mg/mL (9.94 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years