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MAZ51
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MAZ51图片
CAS NO:163655-37-6
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
MAZ51 是一种VEGFR-3酪氨酸激酶的选择性抑制剂。它抑制 VEGF-C 诱导的 VEGFR-3 激活,而没有阻断 VEGF-C 介导的VEGFR2 刺激。它阻止增殖并诱导多种肿瘤细胞凋亡,具有抗肿瘤活性。

产品描述

MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.

体外活性

MAZ51 is able to block the proliferation of VEGFR-3-expressing human endothelial cells and is less potently able to induce their apoptosis.?MAZ51 also inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines[1].

体内活性

In vivo, MAZ51 significantly inhibits the growth of rat mammary carcinomas.?These data establish MAZ51 as a compound with antitumor properties that inhibits tumor growth directly and also indirectly by interfering with tumor-host interactions[1].

Cas No.

163655-37-6

分子式

C21H18N2O

分子量

314.388

储存和溶解度

DMSO:3.33 mg/ml(10.59 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years