PF-06446846 是口服有活性的PCSK9抑制剂。它能够在密码子区域附近阻断 80S ribosome，选择性地直接抑制 PCSK9 的翻译。

PF 06446846 is a potent and selective PCSK9 inhibitor

PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?PF-06446846 is highly selective for the inhibition of PCSK9 translation.?The mechanism of action employed by PF-06446846 reveals a previously unexpected tunability of the human ribosome that allows small molecules to specifically block translation of individual transcripts.

1632250-49-7

C22H20ClN7O

433.9

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years