ITI214 是一种中枢神经系统活性抑制剂，具有口服生物活性的PDE1抑制剂 (Kiof 58 pM)，对其他 PDE 家族成员和一系列酶、受体、转运体和离子通道具有良好的选择性，在各种运动和认知功能的动物模型中显示出有效性。

ITI214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).

1642303-38-5

C29H29FN7O5P

605.56

ITI214

DMSO:30 mg/mL (49.54 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years