RP-001 is a selective agonist of picomolar short-acting S1P1 (EDG1)(EC50 of 9 pM), has little activity on S1P2-S1P4 and only moderate affinity for S1P5.

dose-dependent lymphopenia of CD4+ T cells elicited by RP-001. RP-001 induces acute lymphopenia with rapid recovery to untreated levels.

Dose-dependent rapid lymphopenia caused by RP-001 (EC50 of 0.03 mg/kg).

1306761-53-4

C24H24N4O4

432.47

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years