产品描述
RP-001 hydrochloride is a selective agonist of picomolar short-acting S1P1 (EDG1)(EC50 of 9 pM), has little activity on S1P2-S1P4 and only moderate affinity for S1P5.
体外活性
Dose-dependent lymphopenia of CD4+ T cells elicited by RP-001 hydrochloride. RP-001 hydrochloride induces acute lymphopenia with rapid recovery to untreated levels.
体内活性
Dose-dependent rapid lymphopenia caused by RP-001 hydrochloride(EC50 of 0.03 mg/kg).
Cas No.
1781880-34-9
分子式
C24H25ClN4O4
分子量
468.93
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years