MAK683-CH2CH2COOH 与 EED (胚胎外胚层发育蛋白) 结合。基于MAK683-CH2CH2COOH 和 E3 泛素连接酶的 VHL 配体,设计了靶向EED的PROTACs, PROTAC EED degrader-1 和 PROTAC EED degrader-2 。
产品描述
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design EED-Targeted PROTAC which are EED degrader-1 and PROTAC EED degrader-2 [1].
体外活性
With 14 days treatment, MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI 50 of 14 nM [1].
Cas No.
2639882-68-9
分子式
C23H21FN6O3
分子量
448.45
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years