(S,R,S)-AHPC-PEG2-NH2 hydrochloride 包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物，可用于 PROTAC 的合成分子。

(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG2-NH2 hydrochloride incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTAC.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

2097973-72-1

C28H42ClN5O6S

612.18

VH032-PEG2-NH2 hydrochloride;VHL Ligand-Linker Conjugates 3 hydrochloride;E3 ligase Ligand-Linker Conjugates 6

DMSO:100 mg/mL (163.35 mM),Need ultrasonic
H2O:100 mg/mL (163.35 mM ),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years