FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology.

FKBP12 PROTAC RC32 (RC32;?0.1-1000 nM;?for 12?hours) results in 50% protein degradation (DC50) of ~0.3?nM after only 12?hours of treatment.

RC32 efficiently degrades the FKBP12 protein in most of the organs examined in Bama pigs (20?kg) . ?RC32 efficiently degrades FKBP12 in the heart, liver, kidney, spleen, lung, and stomach of rhesus monkeys.?RC32 degrades the FKBP12 protein in most of the organs of treated mice, except for the brain after only 1 day of treatment in mice. ?RC32 significantly degrades FKBP12 in mice.

2375555-66-9

C75H107N7O20

1426.69

RC32

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years