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Antitumor agent-19
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Antitumor agent-19图片
CAS NO:2379727-90-7
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品介绍
Antitumor agent-19 是一种肿瘤相关巨噬细胞的调节剂,在 RAW 264.7 细胞和 BMDM 细胞中的 EC50 分别为 17.18 μM 和 18.87 μM。

产品描述

Antitumor agent-19 is a modulator of tumor-associated macrophages with EC50s of 17.18 μM and 18.87 μM in the RAW 264.7 cells and the BMDM cells.

体外活性

In RAW 264.7 cells, Antitumor agent-19 (10 μM, 20 μM, or 50 μM) effectively and dose-dependently induces the expression of M1-phenotype macrophage markers including IL-1β, TNF-α, iNOS and IL-12α. Antitumor agent-19 dose-dependently repolarizes tumor-associated macrophages from M1 (anti-tumor) and M2 (pro-tumor)[1].

体内活性

In C57BL/6 female mice with lewis lung cancer cells, Antitumor agent-19 (5 mg/kg; i.p.) remarkably inhibits tumor growth. The synergy of Antitumor agent-19 with anti-PD-1 antibody shows more superior antineoplastic effects in vivo[1].

Cas No.

2379727-90-7

分子式

C24H21ClF3N5O

分子量

487.91

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years