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Millepachine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Millepachine图片
CAS NO:1393922-01-4
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Millepachine 是分离自中草药Millettia pachycarpaBenth 的查尔酮,在体内外对多种人类癌细胞均显示出强大的抗增殖作用。

产品描述

Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells.

体外活性

Millepachine (2-8 μM; 24 h) inhibits ATP-binding cassette transporter activity in A2780CP cells. Millepachine (2-8 μM; 24 or 48 h) induces significant G2/M arrest and apoptosis of cisplatin-sensitive A2780S and cisplatin-resistant A2780CP cells. The percentage of cells in the G2/M fraction increased from 15.99% in vehicle cells to 24.93%, 60.67%, and 77.31% at dose of 2, 4, and 8 μM in A2780S cells, respectively. Millepachine (2-8 μM; 24 h) decreases topoisomerase II levels in A2780S and A2780CP cells. Millepachine (1.25-20 μM; 48 h) remarkably inhibits the proliferation of cisplatin-resistant A2780CP cells with an IC50 of 4 μM[1].

体内活性

Millepachine (20 mg/kg; i.v.) reduced tumor volume and tumor weight with the inhibitory rate of 73.21% and 65.58% in A2780S and A2780CP xenograft models, respectively. Millepachine does not induce acquired drug resistance in an excised A2780S xenograft model[1].

Cas No.

1393922-01-4

分子式

C22H22O4

分子量

350.414

储存和溶解度

DMSO:100 mg/mL (285.38 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years