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Kavain
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Kavain图片
CAS NO:3155-48-4
包装与价格:
包装价格(元)
5 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Kavain是从卡瓦胡椒中分离出来的卡瓦酸内酯,可以正向调控GABAA受体,具有抗焦虑作用。

产品描述

Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of transcriptional factors such as NF-kB and LITAF.

体内活性

Kavain treatment in RAW264.7 cells deactivated MyD88 and Akt, inhibited LITAF, and reduced the production of TNF-α, IL-27, and MIG in response to LPS. Similarly, it had a significant in vivo anti-inflammatory effect on wild-type (WT) mice that developed Collagen Antibody Induced Arthritis (CAIA).

Cas No.

3155-48-4

分子式

C14H14O3

分子量

230.263

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years