Broflanilide 是昆虫抗狄氏剂 GABA 受体拮抗剂，可代谢为 Desmethyl-Broflanilide，抑制斜纹夜蛾 RDL GABAR，IC50值为 1.3 nM。

Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR with IC50 of 1.3 nM.

Broflanilide is an insecticide and metabolized to desmethyl-broflanilide. Desmethyl-broflanilide shows weak activity against human GABAA α1β2γ2 receptor, the mammalian GABAA α1β3γ2 receptor and human glycine receptor (GlyR) α1β with IC50s >3 μM, and less potently inhibits GlyR α1-A288Gβ and GlyR α1-A288G with IC50s of 0.706 and 0.149 μM respectively.

1207727-04-5

C25H14BrF11N2O2

663.28

DMSO:225 mg/mL (339.22 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years