Tipepidine hydrochloride 对多巴胺 D2受体介导的GIRK 电流 (IDA(GIRK))具有可逆的抑制作用,从而激活 VTA 多巴胺神经元, 对 IDA(GIRK)的IC50为 7.0 μM。它是镇咳药,具有抗抑郁样作用。
产品描述
Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.
体内活性
In ACTH-treated rats, Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test. In ACTH-treated rats, Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) [2].
Cas No.
1449686-84-3
分子式
C15H18ClNS2
分子量
311.89
储存和溶解度
DMSO:41.67 mg/mL (133.60 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years