Guanfu base I is an active metabolite of Guanfu base A, isolated from Aconitum coreanum. It have a potent anti-arrhythmic effect.

The pharmacokinetics of Guanfu base I in Sprague-Dawley rats is examined.?The method is linear in the 0.05-20 μg/mL concentration range.?The recovery of Guanfu base I is more than 80%.?The intraday and interday precision, expressed as the relative standard deviation, is generally good.?After intravenous injection dosing, plasma Guanfu base I concentration declined in a bi-phasic manner with a terminal elimination half-life of 2.49 hours.?The total plasma clearance value is 1.46 L/h/kg.?After oral dosing, the plasma Guanfu base I concentration reached a maximum within 0.5 hour.?The absolute bioavailability of Guanfu base I is 71.31%.

110225-59-7

C22H29NO5

387.47

Acorine

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years