OMDM-1 是有效选择性的代谢稳定 anandamide 细胞摄取抑制剂，Ki=为2.4 μM。

OMDM-1 is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor with a Ki of 2.4 μM.

OMDM-1 is anovel potent and selective inhibitors of ACU?and one "hybrid" agonist of CB(1) and VR1 receptors (OMDM-6).?Unlike other compounds of the same type, OMDM-1, OMDM-2, and OMDM-6 were very stable to enzymatic hydrolysis by rat brain homogenates.The (R)- and, particularly, the (S)-1'-(4-hydroxybenzyl) derivatives of N-oleoylethanolamine and AEA (OMDM-1, OMDM-2, OMDM-3, and OMDM-4) inhibited to a varied extent ACU in RBL-2H3 cells (K(i) ranging between 2.4 and 17.7 micro M), the oleoyl analogues (OMDM-1 and OMDM-2, K(i) 2.4 and 3.0 micro M, respectively) being 6- to 7-fold more potent than the arachidonoyl analogues (OMDM-3 and OMDM-4). [1].

616884-62-9

C27H45NO3

431.65

(Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide

dimethyl formamide:30mg/ml
DMSO:≤30mg/ml
Ethanol:30mg/ml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years