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AHN 1-055 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:202646-03-5
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride
产品介绍
AHN 1-055 hydrochloride 与多巴胺转运蛋白具有高亲和力,是多巴胺摄取抑制剂,IC50为 71 nM。

产品描述

AHN 1-055 hydrochloride is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM). AHN 1-055 hydrochloride may serve as a lead for the development of agents for the treatment of cocaine abuse.

体内活性

In adult male Sprague Dawley rats, AHN 1-055 hydrochloride (5 mg/kg; i.v.) inhibited the uptaking of brain dopamine with an IC50 of 311.8 ng/ml. The Cmax and T1/2 are 1.48 mg/L and 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution[1].

Cas No.

202646-03-5

分子式

C21H24ClF2NO

分子量

379.88

别名

3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride

储存和溶解度

DMSO:125 mg/mL (329.06 mM)
H2O:33.33 mg/mL (87.74 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years