AHN 1-055 hydrochloride 与多巴胺转运蛋白具有高亲和力，是多巴胺摄取抑制剂，IC50为 71 nM。

AHN 1-055 hydrochloride is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM). AHN 1-055 hydrochloride may serve as a lead for the development of agents for the treatment of cocaine abuse.

In adult male Sprague Dawley rats, AHN 1-055 hydrochloride (5 mg/kg; i.v.) inhibited the uptaking of brain dopamine with an IC50 of 311.8 ng/ml. The Cmax and T1/2 are 1.48 mg/L and 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution[1].

202646-03-5

C21H24ClF2NO

379.88

3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride

DMSO:125 mg/mL (329.06 mM)
H2O:33.33 mg/mL (87.74 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years