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Levobetaxolol hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Levobetaxolol hydrochloride图片
CAS NO:116209-55-3
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Levobetaxolol HCl
左旋倍他洛尔
AL-1577A
(S)-Betaxolol hydrochloride
Betaxon
产品介绍
Levobetaxolol HCl 是 β-肾上腺素能受体抑制剂 (β阻滞剂) 。它具有降低眼压的作用,可用于研究青光眼。

产品描述

Levobetaxolol hydrochloride is a beta-adrenergic receptor inhibitor (beta blocker), used to lower the pressure in the eye in treating conditions such as glaucoma.

体外活性

Levobetaxolol potently antagonizes functional activities at cloned human β1 and β2 receptors, and also at guinea pig atrial β1, tracheal β2 and rat colonic β3 receptors with IC50s of 33.2 nM, 2970 nM and 709 nM, respectively. Levobetaxolol (Ki = 16.4 nM) is more potent than dextrobetaxolol (Ki = 2.97 μM) at inhibiting isoproterenol-induced cAMP production in human non-pigmented ciliary epithelial cells. [1] Levobetaxolol (topically applied) has been shown to reach the back of the eye in sufficient quantities to protect retinal ganglion cells from various types of insults. Levobetaxolol displaces [3H]-nitrendipine for L-type voltage-dependent calcium channel receptor with IC50 of 29.5 μM in rat cortex. Levobetaxolol reduces NMDA-stimulated 45Ca2+ influx by 47.3%. Levobetaxolol (topically applied) reduces the b-wave amplitude caused by ischaemia/reperfusion. [2]

体内活性

Levobetaxolol (150 mg/eye) is more potent than dextrobetaxolol, reducing intraocular pressure by 25.9% in conscious ocular hypertensive cynomolgus monkeys. [1] Levobetaxolol (20 mg/kg) significant protects retinal function and results in significantly thicker the RPE and outer nuclear layer in a photic-induced retinopathy rat model. Levobetaxolol (20 mg/kg) results in a 10-fold up-regulation of bFGF and a two-fold up-regulation of CNTF mRNA levels, trophic factors that have been shown to inhibit retinal degeneration in a number of species. [3]

Cas No.

116209-55-3

分子式

C18H30ClNO3

分子量

343.89

别名

Levobetaxolol HCl;左旋倍他洛尔;AL-1577A;(S)-Betaxolol hydrochloride;Betaxon

储存和溶解度

Ethanol:64 mg/mL (186.1 mM)
DMSO:64 mg/mL (186.1 mM)
H2O:63 mg/mL (183.2 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years