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L-765314
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-765314图片
CAS NO:189349-50-6
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
L-765314 是一种 α1b 肾上腺素能受体的选择性拮抗剂,其在大鼠和人体中的Ki分别为 5.4 nM 和 2.0 nM。

产品描述

L-765314 is a drug which acts as a potent and selective antagonist for the Alpha-1 adrenergic receptor subtype α1B. It has mainly been used to investigate the role of α1B receptors in the regulation of blood pressure.

体内活性

L-765314 shows weak potency for inhibiting the pressor response to either phenylephrine or A-61603 (AD25>3 mg/kg for each).?On the basis of the inhibition of pressor responses to the R1a subtype selective agonist A-61603, L-765314 appears to be selective versus the R1a receptor up to a dose of 0.3 mg/kg.?The results of hypotensive potency in rats show that both L-765314 and terazosin tend to decrease heart rate (about 25 bpm at 1 mg/kg iv)[1]

Cas No.

189349-50-6

分子式

C27H34N6O5

分子量

522.606

储存和溶解度

DMSO:50 mg/mL (95.68 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years