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Stachydrine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Stachydrine图片
CAS NO:471-87-4
包装与价格:
包装价格(元)
20 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
N,N-Dimethyl-L-proline
Methyl hygrate betaine
水苏碱
Proline betaine
L-stachydrine
产品介绍
Stachydrine 是中国草本植物益母草的主要成分,具有促进血液循环和消除血瘀的功效。Stachydrine能够抑制NF-κB信号通路。

产品描述

Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway. Stachydrine is a biomarker for the consumption of citrus fruits.

体外活性

Various concentrations of stachydrine intervention (10(-6) - 10(-4) mol/L) showed better anti-hypertrophic effect and decreased the number of ROS positive myocardial cell (P<0.05). Meanwhile, intervention of stachydrine significantly suppressed the level of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus (P<0.05).

细胞实验

Myocardial cells of neonatal rats were incubated with angiotensin II for 48 hours to establish myocardial cell hypertrophy models. The cell surface area and protein/DNA ratio were detected as index for hypertrophy of myocardial cells. ROS positive myocardial cell were counted by means of flow cytometry, the expression of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus were also detected by Western blot.

Cas No.

471-87-4

分子式

C7H13NO2

分子量

143.186

别名

N,N-Dimethyl-L-proline;Methyl hygrate betaine;水苏碱;Proline betaine;L-stachydrine

储存和溶解度

H2O:32 mg/mL (223.49 mM)
DMSO:26 mg/mL (181.59 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years