Synephrine 是来自Citrus aurantium的α-adrenergic和β-adrenergic激动剂,是一种生物碱。它也是一种拟交感神经化合物,能够用于减肥。
产品描述
Synephrine is sympathetic alpha-adrenergic agonist used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.
体外活性
Synephrine is a compound commonly used for weight loss. Synephrine has gained significant popularity as an alternative to ephedrine. Products containing bitter orange or synephrine are suspected of causing adverse cardiovascular reactions. [1] [2] Synephrine can stimulate glucose consumption (Glut4-dependent glucose uptake) by stimulating AMPK activity, regardless of insulin-stimulated PI3 kinase-Akt activity in L6 skeletal muscle cells. [3]
体内活性
LD50: Mice >1000 mg/kg (s.c.) [4]
Cas No.
94-07-5
分子式
C9H13NO2
分子量
167.21
别名
辛弗林;Oxedrine
储存和溶解度
Ethanol:2 mg/mL (11.96 mM),warmed
DMSO:31 mg/mL (185.4 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years