Coryneine 是从附子根中提取的多巴胺的季铵衍生物。

Coryneine is a quaternary ammonium derivative of dopamine derived from aconite root.

Coryneine (20-150 microM) blocked the nerve-evoked twitch response without affecting the contraction evoked by electrical stimulation of the muscle[1]. Coryneine (20 microM-2mM) itself depolarized the endplate membrane and this effect was reversibly suppressed by 1 and 5 microM pancuronium[1]. Coryneine 30 microM-10mM) produced contractions of denervated muscles in a concentration-dependent manner and the effects were reduced by 70nM pancuronium[1].

7224-66-0

Trimethyl(3,4-dihydroxyphenethyl)aminium;2-(3,4-dihydroxyphenyl)ethyl-trimethylazanium;棍掌碱;Dopamine methiodide;Quaternary dopamine

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years