MT-4 可阻断肿瘤细胞和肿瘤niche 表面的TG2/FN 复合体。 MT-4抑制卵巢癌(OC)细胞与腹膜的黏附。

MT-4 inhibits the adhesion of ovarian cancer (OC) cells to the peritoneum.

In an in vivo model measuring intraperitoneal dissemination, MT4 and MT6 inhibited the adhesion of ovarian cancer cells to the peritoneum. Pretreatment with MT4 also sensitized ovarian cancer cells to paclitaxel. The data support continued optimization of the new class of SMIs that block the TG2/FN complex at the interface between cancer cells and the tumor niche[1].

2327925-35-7

C21H23N5O

361.44

DMSO:90mg/mL (249mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years