NP-G2-044 是fascin蛋白抑制剂，具有口服活性，IC50值约为 2 μM。它可阻断肿瘤转移并增强抗肿瘤免疫应答。

NP-G2-044 is an orally active fascin inhibitor, with an IC50 of ~2 μM. It blocks tumor metastasis and increases antitumor immune response.

NP-G2-044 inhibits the migration of MDA-MB-231 tumor cells with an IC50?~10 μM. It decreases filopodial formation resulting in decreased lamellipodial formation[1].

NP-G2-044 (100 mg/kg; i.p.; daily for 18 days) inhibits breast tumor metastasis in mouse models[1].

1807454-59-6

C21H16F3N3O2

399.373

DMSO:100 mg/mL (250.39 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years