Nitroaspirin 是一氧化氮供体和阿司匹林的硝基衍生物，与 Aspirin 结合可抑制环氧合酶=，可作为 COX-1 的直接和不可逆抑制剂。 它通过下调 EGFR/PI3K/STAT3 信号传导和调节 BCL-2 家族蛋白，显着诱导顺铂耐药人卵巢癌细胞的细胞周期停滞和凋亡，具有抗血栓和抗血小板特性。

Nitroaspirin is a nitric oxide donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin induces significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins. Nitroaspirin has antithrombotic and antiplatelet properties and acts as a direct and irreversible inhibitor of COX-1.

175033-36-0

C16H13NO7

331.28

2-乙酰氧基苯甲酸-3-硝酸甲基苯酯;NCX 4016

DMSO:55 mg/ml (166.02 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years