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UC-112
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UC-112图片
CAS NO:383392-66-3
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品介绍
UC-112是凋亡抑制蛋白IAP新型高效抑制剂,癌细胞IC50值0.7-3.4uM。

产品描述

UC-112 is a novel potent IAP inhibitor and potently inhibits cell growth in two human melanoma and two human prostate cancer cell lines (IC50=0.7-3.4 uM).

体外活性

UC-112 also effectively inhibits the growth of P-glycoprotein (P-gp)-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at a concentration as low as 1 μM. Coincubation of UC-112 with a known proteasome inhibitor Z-Leu-Leu-Leu-CHO rescued survivin inhibition, consistent with the anticipated mechanism of action for UC-112[1].

体内活性

UC-112 strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo [1].

Cas No.

383392-66-3

分子式

C22H24N2O2

分子量

348.44

储存和溶解度

DMSO:30.6mg/mL (87.8mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years