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Alkannin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:23444-65-7
包装与价格:
包装价格(元)
5 mg电议
50 mg电议
100 mg电议

产品介绍
ALKannin 是一种有效且特异性的肿瘤型丙酮酸激酶-M2 (PKM2) 抑制剂。ALKannin 不抑制 PKM1 和丙酮酸激酶-L (PKL)。ALKannin 可作于抗肿瘤的研究。

产品描述

Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent [1].

体外活性

Alkannin is a potent and specific inhibitor to PKM2, an enzyme that dictates the last rate-limiting step of glycolysis, which is essential for cancer cells’ proliferation and survival. In the absence of D-fructose-1,6-bisphosphate (FBP), the IC 50 of Alkannin is 0.3 μM. In the presence of FBP (125 μM), the IC 50 of Alkannin is 0.9 μM, respectively. Alkannin effectively inhibits the cellular glycolytic flux in cancer cells dominantly expressing PKM2 [1]. Alkannin (2.5-20 μM, 1 hour) inhibit the rates of cellular lactate production and glucose consumption [1]. Western Blot Analysis [1] Cell Line: MCF-7 and A549 express PKM2 but not PKM1 and PKL Concentration: 0-20 μM Incubation Time: 1 hour Result: Inhibited the cellular glycolytic rate in a concentration-dependent manner.

Cas No.

23444-65-7

分子式

C16H16O5

分子量

288.3

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years