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Kuwanon E
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Kuwanon E图片
CAS NO:68401-05-8
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
5'-[(E)-3,7-二甲基-2,6-辛二烯基]-2',4',5,7-四羟基黄烷酮
桑皮酮 E
桑黄酮 E
产品介绍

产品描述

Kuwanon E inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, respectively. Kuwanon E also inhibited the production of MUC5AC mucin induced by PMA from NCI-H292 cells,.

体外活性

Nine flavonoids displaying cholinesterase inhibitory activity were isolated from the root bark oiMorus Ihou L., a cultivated edible plant. The isolated compounds were identified as a new flavone (1), 5'-geranyl-5,7,2',4'-tetrahydroxyflavone (2), kuwanon U (3), Kuwanon E (4), morusin (5), morusinol (6), cyclomorusin (7), neocyclomorusin (8), and kuwanon C (9). All compounds apart from compound 6 inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, respectively. The new compound was char-actierized as S'-geranyl-4'-methoxv-5,7,2'-trihydroxyflavone (1). It showed the most potent inhibitory activity (K i = 3.1 μM for AChE, K i= 1.74 μM for BChE). Lineweaver-Burk and Dixon plots and their secondary replots indicated that flavones (5-9) with prenyl substitution on C-3 were noncompetitive inhibitors, whereas those unsubstituted (1 -4) at C-3 were mixed inhibitors of both AChE and BChE.

Cas No.

68401-05-8

分子式

C25H28O6

分子量

424.49

别名

5'-[(E)-3,7-二甲基-2,6-辛二烯基]-2',4',5,7-四羟基黄烷酮;桑皮酮 E;桑黄酮 E

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years