CDDO-2P-Im 在小鼠肺癌模型中显示出化学预防作用并降低了肺肿瘤的大小和严重程度。

CDDO-2P-Im shows chemopreventive effect and reduces the size and severity of the lung tumors in the mouse lung cancer model.

In RAW264.7 cells, CDDO-2P-Im suppresses NO production (IC50: 5.8 nM). CDDO-2P-Im (100 nM) induces differentiation of U937 cells[1].

CDDO-2P-Im significantly elevates heme oxygenase-1 and quinone reductase mRNA and protein levels. In A/J mice, CDDO-2P-Im (50-200 mg/kg) decreases the number, size, and severity of tumors[1].

1883650-96-1

C39H46N4O3

618.81

CDDO-2-P-Im

DMSO:112.5mg/mL (181.8mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years