BMS-191011 是一种大电导 Ca2+激活的钾通道 (Ca2+-activated potassium (maxi-K) channel) 激活剂,在中风模型中有研究价值。
产品描述
BMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models
体内活性
In vivo, BMS 191011 (10-100 μg/kg, i.v.) increases the diameter of retinal arterioles without affecting blood pressure or heart rate in rats, an effect that is reversed by the BKCa channel blocker iberiotoxin[1]
Cas No.
202821-81-6
分子式
C16H10ClF3N2O3
分子量
370.71
别名
BMS-A
储存和溶解度
DMSO:125 mg/mL (337.19 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years