Simvastatin acid (Tenivastatin) calcium hydrate 是一种具有口服活性的 HMG-CoA 还原酶 (HMGCR) 抑制剂。Simvastatin acid calcium hydrate 降低吲哚酚硫酸盐 (indoxyl sulfate) 介导的活性氧 (ROS) 产生。Simvastatin acid calcium hydrate 也可调节心肌细胞和转染 OATP3A1 基因的 HEK293 细胞的 OATP3A1 表达。

Simvastatin acid (Tenivastatin) calcium hydrate is an orally active HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid calcium hydrate reduces indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid calcium hydrate can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene [1] [2].

Simvastatin acid (0.1-20 μM; 30 min) significantly decreases ROS production between 8.9% and 43% in indoxyl sulfate-treated hCM cells [2]. Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells [2]. Western Blot Analysis [2] Cell Line: hCM and HEK293 (transfected with OATP3A1) Concentration: 0.1, 1, 10 and 20 μM Incubation Time: 24 h Result: Altered the protein expression of OATP3A1 in hCMs and OATP3A1-expressing cells. Decreased 1.5% to 90% in OATP3A1 expression with a dose-dependent manner in both hCMs and OATP3A1-expressing cells.

530112-57-3

C25H40O6

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years